Despair, hopelessness, depression: complete loss of faith or hope in a potentially different future. Life is only survival, only going through the motions, if at all. THIS is what every Dystopian novel needs to convey, and WOLF brings it on in spades.
Our protagonist Johnny Wolf is a loser. Aging, obese, smoking, divorced, a failed salesman--but his saving grace is his love for Dogs, especially Sindra, his childhood companion, who lived 20 years before her disappearance (or death), at the time all the dogs went away (or were killed by the police). In fact, Johnny Wolf has internalized his dog: he injects a little bit of Sindra's heart or liver, every day.
Johnny is/was a salesman. He knows all the sales lessons by heart; and somewhat self-analytical (intermittently) he recognizes where he falls short.
Johnny may be an anti-hero, held in contempt by ex-wife and colleagues; but in the End, Johnny Wolf proves his mettle.